DNA and key enzymes being damaged by smokeless tobacco

According to a new research, adverse effects of smokeless tabacco are not limited just to the mouth it can also damage the normal functioning of the enzymes contained in the human body.

The enzymes are said to play an important role in the hormone production, namely, sex hormones, oestrogen and testosterone, production of vitamin D and cholesterol is also said to be affected.

Smokeless tobacco is also said to damage the genetic material contained in the kidneys, liver and lungs.

However scientists have little information on the adverse effects of smokeless tobacco on other parts of the human body.

But it is mentioned by colleagues and Krishna Khanduja that they have noted widespread recognition on the harmful effects of smokeless tobacco on the mouth which also include the risk of getting oral cancer and gum disease.

The chemicals and potential carcinogens contained in the extracts of smokeless products are absorbed into the blood stream and are circulated through the body. Laboratory rats were used for the evaluation of the changes in genetic material and enzymes by using the extracts if smokeless tobacco.

The study states that, "not only did smokeless tobacco damage the genetic material in DNA but also alters the function of the, family of enzymes called CYP-450."

The study also states, "worldwide use of products is noted but are most commonly used in places like, Southeast Asia, Northern Africa and the Mediterranean region,"

The study also adds, "the users of the smokeless tobacco products are highly unaware of the adverse effects, therefore, smokeless products are used to treat, headaches, toothaches and stomachaches.

This false impression increases the use of smokeless tobacco products among youngsters the use of these harmful smokeless tobacco products is increasing among children, teenagers and women apart from men. Immigrants from the South Asian region and other dental and medical students also have increased usage of these products."

The adverse effects of these products has been on the rise although the harmful effects are known to researchers.

The study has also been published in the ACS' monthly journal of chemical research in toxicology.